Episode 126: PFA and Delayed Myocardial Ischemia and Malignant Arrhythmias

In this Breaking News conversation, #HRStv host Daniel M. Alyesh, MD, FHRS, is joined by Melanie Gunawardene, MD, FHRS, and Julian Chun, MD, to discuss a recent Circulation Research Letter describing life-threatening delayed myocardial ischemia and arrhythmias following PFA for AFib. They explore the proposed mechanisms and its correlation with the MANIFEST US study, as well as comparisons with thermal ablation data.

Additional Resources

Circulation. 2026;153:00–00. DOI: 10.1161/CIRCULATIONAHA.125.077983
Turagam, M, Aryana, A, Day, J. et al. Multicenter Study on the Safety of Pulsed Field Ablation in Over 40,000 Patients: MANIFEST-US. JACC. null2025, 0 (0)
Circ Arrhythm Electrophysiol. 2023;16:e011365. DOI: 10.1161/CIRCEP.122.011365

Listen on:

• Apple Podcasts
• Spotify
• iHeartRadio
• Audible
• Deezer

Want to explore more content? Catch the full video versions and more on our channel – [Heart Rhythm TV].