The Lead Episode 103: A Discussion of Independent External Evaluation of Pediatric Hypertrophic Cardiomyopathy Risk Scores… Live at HRS 2025 in San Diego

Discussion Topic: Independent External Evaluation of Pediatric Hypertrophic Cardiomyopathy Risk Scores in Predicting Severe Ventricular Arrhythmias

Join host Elizabeth S DeWitt, MD, CEPS-P, and episode guests Cheyenne Beach, MD, FHRS, CEPS-P, and Robert Przybylski, MD as they discuss Sudden cardiac death is the leading cause of mortality in children with hypertrophic cardiomyopathy (HCM). Two risk scores—HCM Risk-Kids and PRIMaCY—have been developed to estimate 5-year risk, but their performance in an independent cohort showed limitations. Both tools tended to overestimate risk and showed imperfect ability to distinguish between low- and high-risk patients. However, their predictive accuracy significantly improved when risk assessments were repeated over time during follow-up.

Host: Elizabeth S DeWitt, MD, CEPS-P
Guests:  Cheyenne Beach, MD, FHRS, CEPS-P and Robert Przybylski, MD

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