The Lead Episode 25: A Discussion of Feasibility and Safety of Intravenous Sotalol Leading in Adult Patients with AFib (DASH-AF)

Discussion Topic: Feasibility and Safety of Intravenous Sotalol Loading in Adult Patients with AFib (DASH-AF)

Host: Deepthy Varghese, MSN, ACNP, FNP
Guests: Alok Gambhir, MD, DPhil, FHRS and Megan LaBreck, PharmD, BCPD, CACP

A total of 120 patients from 3 centers were enrolled from 2021 to 2022 in the IV loading group (compared with type of AF– and renal function–matched patients in the conventional PO loading cohort). This study demonstrated no significant change in ΔQTc in both groups, with a significantly lower number of patients requiring dose adjustment in the IV arm compared with the PO arm (4.1% vs 16.6%; P = 0.003). This led to potential cost savings of up to $3,500.68 per admission. The DASH-AF trial shows that rapid IV sotalol loading in atrial fibrillation/flutter patients for rhythm control is feasible and safe compared with conventional oral loading with significant cost reduction. (Feasibility and Safety of Intravenous Sotalol Administered as a Loading Dose to Initiate Oral Sotalol Therapy in Adult Patients With Atrial Fibrillation [DASH-AF]; NCT04473807)

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