Discussion Topic: New-Onset Atrial Fibrillation Prediction: the HARMS2-AF Risk Score
Deepthy Varghese, MSN, ACNP, FNP, of Northside Hospital, is joined by guests Sandeep K. Goyal, MD, FHRS, Piedmont Heart Institute, and Andrea M. Russo, MD, FHRS, Cooper University Hospital. to discuss the article explores that development and validation of the HARMS2-AF score, a novel lifestyle risk assessment tool for identifying atrial fibrillation (AF) risk in the general population. Using data from the UK Biobank and Framingham Heart Study, the score, derived through Cox proportional hazards regression, includes variables like hypertension, age, body mass index, sex, sleep apnea, smoking, and alcohol. Physical inactivity and diabetes were not significant predictors. The score demonstrated effective predictive performance in both cohorts, outperforming existing models like Framingham-AF and ARIC, and comparable to CHARGE-AF. In conclusion, the HARMS2-AF score is a valuable tool for lifestyle-related AF risk identification, aiding in population screening and potential early intervention.
Host: Deepthy Varghese, MSN, ACNP, FNP
Guests: Sandeep K. Goyal, MD, FHRS and Andrea M. Russo, MD, FHRS
Speaker and Article Information: Download
Visual Aid: Download
Topic
- The Lead
Resource Type
- Podcasts
Related Resources

Podcasts
The Lead Episode 118: A Discussion of Atrial Fibrillation Catheter Ablation, Brain Glymphatic function, and Cognitive performance.
August 28, 2025

Podcasts
The Lead Episode 117: A Discussion of Can ICD Electrograms Help Ventricular Tachycardia Ablation?
August 21, 2025

Podcasts
The Lead Episode 116: A Discussion of Multicenter Results of a Novel Pediatric Pacemaker...
August 14, 2025