The Lead Episode 88: A Discussion of Ablation for Atrial Fibrillation in Patients With Rare Pathogenic Variants in Cardiomyopathy and Arrhythmia Genes

Discussion Topic: Ablation for Atrial Fibrillation in Patients With Rare Pathogenic Variants in Cardiomyopathy and Arrhythmia Genes

William H. Sauer, MD, FHRS, CCDS, Brigham and Women’s Hospital is joined by Ezim Ajufo, MD, Brigham and Women’s Hospital and Victor Nauffal, MD, Brigham and Women’s Hospital to discuss the Patients with rare, pathogenic cardiomyopathy (CM) and arrhythmia variants that can present with atrial fibrillation (AF). The efficacy of AF ablation in these patients is unknown. This study tested the hypotheses that: 1) patients with a pathogenic variant in any CM or arrhythmia gene have increased recurrence following AF ablation; and 2) patients with a pathogenic variant associated with a specific gene group (arrhythmogenic left ventricular CM [ALVC], arrhythmogenic right ventricular CM, dilated CM, hypertrophic CM, or a channelopathy) have increased recurrence.

Host: William H. Sauer, MD, FHRS, CCDS
Guests: Ezim Ajufo, MD and Victor Nauffal, MD

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